InnateDB Protein
|
IDBP-294561.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
ATRAID
|
Protein Name
|
chromosome 2 open reading frame 28
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000384033
|
InnateDB Gene
|
IDBG-37567 (ATRAID)
|
Protein Structure
|
|
Function |
Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. {ECO:0000269PubMed:21723284}.
|
Subcellular Localization |
Nucleus envelope. Cell membrane; Single-pass membrane protein. Note=Colocalizes with NELL1 on the nuclear envelope and the perinuclear region.
|
Disease Associations |
|
Tissue Specificity |
Weakly expressed in hematopoietic cell lines. {ECO:0000269PubMed:11042152}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
4
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
GO:0010468
|
regulation of gene expression
|
GO:0030154
|
cell differentiation
|
GO:0030501
|
positive regulation of bone mineralization
|
GO:0033689
|
negative regulation of osteoblast proliferation
|
GO:0045669
|
positive regulation of osteoblast differentiation
|
GO:2000599
|
negative regulation of cyclin catabolic process
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000742
Epidermal growth factor-like domain
|
PFAM |
PF00008
|
PRINTS |
|
PIRSF |
|
SMART |
SM00181
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q6UW56
|
PhosphoSite |
PhosphoSite-Q6UW56
|
TrEMBL |
C9JA62
|
UniProt Splice Variant |
|
Entrez Gene |
51374
|
UniGene |
|
RefSeq |
NP_057169
|
HUGO |
HGNC:24090
|
OMIM |
|
CCDS |
CCDS46243
|
HPRD |
16652
|
IMGT |
|
EMBL |
AB009017
AC013403
AF077037
AF144055
AF275744
AK291894
AY358968
BC002846
BC011006
BC021237
BC035850
CH471053
CR600041
|
GenPept |
AAD27770
AAD31317
AAH02846
AAH11006
AAH21237
AAH35850
AAK69412
AAQ89327
AAX93173
BAF80618
BAF84583
EAX00617
|
|
|