InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TBC1D10A

Summary

InnateDB Protein

IDBP-294567.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBC1D10A

Protein Name

TBC1 domain family, member 10A

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384996

InnateDB Gene

IDBG-4017 (TBC1D10A)

Protein Structure

UniProt Annotation

Function

Acts as GTPase-activating protein for RAB27A, but not for RAB2A, RAB3A, nor RAB4A. {ECO:0000269PubMed:16923811}.

Subcellular Localization

Cell projection, microvillus {ECO:0000269PubMed:16923811}. Note=Localizes to the microvilli- rich region of the syncytiotrophoblast. In melanocytes, located at the periphery of cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005097	Rab GTPase activator activity
GO:0005515	protein binding
GO:0030165	PDZ domain binding

Biological Process

GO:0032313	regulation of Rab GTPase activity
GO:0032851	positive regulation of Rab GTPase activity
GO:0045862	positive regulation of proteolysis
GO:0097202	activation of cysteine-type endopeptidase activity