Version 5.4
Homo sapiens Protein: MTMR3
Summary
InnateDB Protein IDBP-294613.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTMR3
Protein Name myotubularin related protein 3
Synonyms FYVE-DSP1; ZFYVE10;
Species Homo sapiens
Ensembl Protein ENSP00000384651
InnateDB Gene IDBG-3909 (MTMR3)
Protein Structure
UniProt Annotation
Function Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues. {ECO:0000269PubMed:11676921}.
Subcellular Localization Cytoplasm. Membrane; Peripheral membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004438 phosphatidylinositol-3-phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0016791 phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0044281 small molecule metabolic process
GO:0046856 phosphatidylinositol dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000306 FYVE zinc finger
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR010569 Myotubularin-like phosphatase domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF01363
PF06602
PRINTS
PIRSF
SMART SM00064
SM00404
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13615
PhosphoSite PhosphoSite-Q13615
TrEMBL Q9UPM2
UniProt Splice Variant
Entrez Gene 8897
UniGene Hs.599417
RefSeq NP_066576
HUGO HGNC:7451
OMIM 603558
CCDS CCDS13870
HPRD 09151
IMGT
EMBL AB002369 AC003071 AC003681 AC004819 AF233436 AF233437 AF233438 BC142713 BC148216 BC152455 CH471095 CR456525 U58034
GenPept AAB83949 AAB88872 AAC79119 AAF40203 AAF40204 AAF40205 AAI42714 AAI48217 AAI52456 BAA20826 CAG30411 EAW59852 EAW59854 EAW59855

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca