Version 5.4
Homo sapiens Protein: NOLC1
Summary
InnateDB Protein IDBP-294621.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOLC1
Protein Name nucleolar and coiled-body phosphoprotein 1
Synonyms NOPP130; NOPP140; NS5ATP13; P130;
Species Homo sapiens
Ensembl Protein ENSP00000385410
InnateDB Gene IDBG-87811 (NOLC1)
Protein Structure
UniProt Annotation
Function Related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. May play an important role in transcription catalyzed by RNA polymerase I.
Subcellular Localization Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleolus and the cytoplasm. At telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
Experimentally validated
Total 72 [view]
Protein-Protein 66 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006364 rRNA processing
GO:0007000 nucleolus organization
GO:0007049 cell cycle
GO:0007067 mitotic nuclear division
Cellular Component
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0015030 Cajal body
Protein Structure and Domains
PDB ID
InterPro IPR006594 LisH dimerisation motif
IPR007718 SRP40, C-terminal
PFAM PF05022
PRINTS
PIRSF
SMART SM00667
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q14978
PhosphoSite PhosphoSite-Q14978
TrEMBL Q96J17
UniProt Splice Variant
Entrez Gene 9221
UniGene Hs.523238
RefSeq NP_001271317
HUGO HGNC:15608
OMIM 602394
CCDS CCDS65926
HPRD
IMGT
EMBL AK056755 AL500527 AY820769 BC001883 BC006769 CH471066 D21262 Z34289
GenPept AAH01883 AAH06769 AAV67777 BAA04803 BAG51805 CAA84063 CAH72220 EAW49713 EAW49714 EAW49715 EAW49717 EAW49718

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca