InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RASL10A

Summary

InnateDB Protein

IDBP-294705.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASL10A

Protein Name

RAS-like, family 10, member A

Synonyms

RRP22;

Species

Homo sapiens

Ensembl Protein

ENSP00000386095

InnateDB Gene

IDBG-3548 (RASL10A)

Protein Structure

UniProt Annotation

Function

Potent inhibitor of cellular proliferation. {ECO:0000269PubMed:15833841}.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Nucleus, nucleolus {ECO:0000269PubMed:15833841}. Note=May cycle in and out of the nucleolus in a GTP-dependent manner.

Disease Associations

Tissue Specificity

Expression appears to be strictly limited to the central nervous system. {ECO:0000269PubMed:8975699}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007264	small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005730	nucleolus
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR013684 Mitochondrial Rho-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF08477

PRINTS

PR00449

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92737

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

10633

UniGene

Hs.73088

RefSeq

HUGO

HGNC:16954

OMIM

602220

CCDS

HPRD

03744

IMGT

EMBL

AC002059 BC022473 BC040434 BC050739 BC058077 Y07847

GenPept

AAH22473 AAH40434 AAH50739 AAH58077 CAA69175