Version 5.4
Homo sapiens Protein: HYPK
Summary
InnateDB Protein IDBP-294732.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HYPK
Protein Name chromosome 15 open reading frame 63
Synonyms C15orf63;
Species Homo sapiens
Ensembl Protein ENSP00000384474
InnateDB Gene IDBG-402223 (HYPK)
Protein Structure
UniProt Annotation
Function Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10- NAA15 complex-mediated N-terminal acetylation. {ECO:0000269PubMed:17947297, ECO:0000269PubMed:20154145}.
Subcellular Localization Nucleus. Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NX55
PhosphoSite PhosphoSite-Q9NX55
TrEMBL A0A024R5Q1
UniProt Splice Variant
Entrez Gene 25764
UniGene
RefSeq
HUGO HGNC:18418
OMIM 612784
CCDS CCDS10104
HPRD 13724
IMGT
EMBL AC018512 AF049613 AF161485 AK000438 AK022435 BC019262 CH471082
GenPept AAC26849 AAF29100 AAH19262 BAA91165 EAW77241 EAW77242

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca