InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NAA60

Summary

InnateDB Protein

IDBP-294773.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAA60

Protein Name

N(alpha)-acetyltransferase 60, NatF catalytic subunit

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000385903

InnateDB Gene

IDBG-12057 (NAA60)

Protein Structure

UniProt Annotation

Function

Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. {ECO:0000269PubMed:21750686, ECO:0000269PubMed:21981917}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000269PubMed:21981917}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004596	peptide alpha-N-acetyltransferase activity
GO:0008080	N-acetyltransferase activity
GO:0010485	H4 histone acetyltransferase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

Biological Process

GO:0006334	nucleosome assembly
GO:0007059	chromosome segregation
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0017196	N-terminal peptidyl-methionine acetylation
GO:0043967	histone H4 acetylation