InnateDB Protein
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IDBP-294781.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PDE4D
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Protein Name
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phosphodiesterase 4D, cAMP-specific
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Synonyms
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ACRDYS2; DPDE3; HSPDE4D; PDE43; PDE4DN2; STRK1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000384806
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InnateDB Gene
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IDBG-22659 (PDE4D)
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Protein Structure
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Function |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269PubMed:15260978, ECO:0000269PubMed:15576036}.
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Subcellular Localization |
Apical cell membrane {ECO:0000269PubMed:14500724}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity). Colocalized with SHANK2 to the apical membrane of colonic crypt cells. {ECO:0000250}.
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Disease Associations |
Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution.Acrodysostosis 2, with or without hormone resistance (ACRDYS2) [MIM:614613]: A pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems. {ECO:0000269PubMed:22464250, ECO:0000269PubMed:22464252, ECO:0000269PubMed:23033274, ECO:0000269PubMed:23043190}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle. {ECO:0000269PubMed:12834813, ECO:0000269PubMed:17244609}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
46
[view]
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Protein-Protein |
46
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
GO:0002027
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regulation of heart rate
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GO:0006198
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cAMP catabolic process
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GO:0007165
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signal transduction
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GO:0008152
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metabolic process
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GO:0010469
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regulation of receptor activity
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GO:0010880
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regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
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GO:0019933
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cAMP-mediated signaling
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GO:0032729
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positive regulation of interferon-gamma production
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GO:0032743
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positive regulation of interleukin-2 production
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GO:0032754
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positive regulation of interleukin-5 production
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GO:0033137
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negative regulation of peptidyl-serine phosphorylation
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GO:0045822
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negative regulation of heart contraction
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GO:0050852
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T cell receptor signaling pathway
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GO:0060314
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regulation of ryanodine-sensitive calcium-release channel activity
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GO:0061028
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establishment of endothelial barrier
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GO:0071320
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cellular response to cAMP
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GO:0071872
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cellular response to epinephrine stimulus
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GO:0071875
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adrenergic receptor signaling pathway
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GO:0086004
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regulation of cardiac muscle cell contraction
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GO:0086024
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adrenergic receptor signaling pathway involved in positive regulation of heart rate
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GO:1901844
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regulation of cell communication by electrical coupling involved in cardiac conduction
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GO:1901898
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negative regulation of relaxation of cardiac muscle
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Cellular Component |
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PDB ID |
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InterPro |
IPR002073
3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR023088
3\'5\'-cyclic nucleotide phosphodiesterase
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PFAM |
PF00233
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PRINTS |
PR00387
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q08499
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PhosphoSite |
PhosphoSite-Q08499
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TrEMBL |
D6RHE0
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UniProt Splice Variant |
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Entrez Gene |
5144
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UniGene |
Hs.734623
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RefSeq |
NP_001184148
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HUGO |
HGNC:8783
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OMIM |
600129
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CCDS |
CCDS56372
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HPRD |
02530
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IMGT |
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EMBL |
AC008791
AC008804
AC008818
AC008829
AC008833
AC008934
AC012315
AC016591
AC020924
AC026693
AC027322
AC034234
AC091913
AC091955
AC092343
AC109486
AC117527
AF012073
AF012074
AF536975
AF536976
AF536977
AJ250854
AY245866
AY245867
AY388960
BC008390
BC036319
BT007398
L20969
L20970
U02882
U50157
U50158
U50159
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GenPept |
AAA03592
AAA97890
AAA97891
AAA97892
AAC00042
AAC00069
AAC00070
AAC13745
AAH08390
AAH36319
AAN10117
AAN10118
AAN10119
AAP36062
AAP75760
AAP75761
AAQ90404
CAC03757
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