InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MERTK

Summary

InnateDB Protein

IDBP-294828.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MERTK

Protein Name

c-mer proto-oncogene tyrosine kinase

Synonyms

c-mer; MER; RP38;

Species

Homo sapiens

Ensembl Protein

ENSP00000387277

InnateDB Gene

IDBG-66030 (MERTK)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001763 Rhodanese-like domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00581
PF00041
PF01108

PRINTS

PR00109

PIRSF

SMART

SM00450
SM00220
SM00409
SM00060
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt