InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TFDP3

Summary

InnateDB Protein

IDBP-294900.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TFDP3

Protein Name

transcription factor Dp family, member 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000385461

InnateDB Gene

IDBG-86712 (TFDP3)

Protein Structure

UniProt Annotation

Function

Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase. {ECO:0000269PubMed:16418725, ECO:0000269PubMed:17062573, ECO:0000269PubMed:20559320}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Translocates to the nucleus on heterodimerization with E2F family members.

Disease Associations

Tissue Specificity

Predominantly expressed in testis. Low level of expression in pancreas. Highly expressed in ovarian and colon cancer cell lines. {ECO:0000269PubMed:12097419, ECO:0000269PubMed:16418725}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle