InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TCEB2

Summary

InnateDB Protein

IDBP-294926.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCEB2

Protein Name

transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)

Synonyms

ELOB; SIII;

Species

Homo sapiens

Ensembl Protein

ENSP00000386652

InnateDB Gene

IDBG-10956 (TCEB2)

Protein Structure

UniProt Annotation

Function

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC- box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 158 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	158 [view]
Protein-Protein	158 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003746	translation elongation factor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006366	transcription from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006414	translational elongation
GO:0006461	protein complex assembly
GO:0010467	gene expression
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0045087	innate immune response (InnateDB)
GO:0050434	positive regulation of viral transcription
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456	cellular response to hypoxia

Cellular Component

GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0031462	Cul2-RING ubiquitin ligase complex
GO:0031466	Cul5-RING ubiquitin ligase complex
GO:0070062	extracellular vesicular exosome