Version 5.4
Homo sapiens Protein: RNASEK
Summary
InnateDB Protein IDBP-295016.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNASEK
Protein Name ribonuclease, RNase K
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000385440
InnateDB Gene IDBG-281519 (RNASEK)
Protein Structure
UniProt Annotation
Function Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate. {ECO:0000269PubMed:17881363}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:17881363}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004521 endoribonuclease activity
Biological Process
GO:0009303 rRNA transcription
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0005575 cellular_component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P5S7
PhosphoSite PhosphoSite-Q6P5S7
TrEMBL H0YIU3
UniProt Splice Variant
Entrez Gene 440400
UniGene Hs.632232
RefSeq
HUGO HGNC:33911
OMIM
CCDS CCDS45594
HPRD 17568
IMGT
EMBL AC040977 AK289930 AM746459 BC051802 BC062705 BC095436 CH471108
GenPept AAH51802 AAH62705 AAH95436 BAF82619 CAN89245 EAW90275

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca