Homo sapiens Protein: SEPT2 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Protein | IDBP-295039.4 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | SEPT2 | ||||||||||||||||||||||||
Protein Name | septin 2 | ||||||||||||||||||||||||
Synonyms | DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3; | ||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||
Ensembl Protein | ENSP00000385109 | ||||||||||||||||||||||||
InnateDB Gene | IDBG-85139 (SEPT2) | ||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||
Function | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000269PubMed:15774761, ECO:0000269PubMed:17803907, ECO:0000269PubMed:18209106, ECO:0000269PubMed:19145258}. | ||||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:15774761}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:15774761}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:15774761}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:15774761}. Cleavage furrow {ECO:0000269PubMed:15774761}. Midbody {ECO:0000269PubMed:15774761}. Cytoplasm, cell cortex {ECO:0000269PubMed:15774761}. Cell projection, cilium membrane {ECO:0000250}. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria. In epithelial cells, colocalizes with polyglutamylated tubulin around the trans-Golgi network, as well as juxatnuclear and proximal Golgi apparatus. Localizes at the base of the cilia near the morphological distinction between the cilia and plasma membranes. | ||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||
Tissue Specificity | Widely expressed. Up-regulated in liver cancer. {ECO:0000269PubMed:15915442, ECO:0000269PubMed:19165576}. | ||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 71 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||
InterPro |
IPR000038
Cell division protein GTP binding IPR008113 Septin 2 IPR016491 Septin IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00735
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PRINTS |
PR01740
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PIRSF |
PIRSF006698
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SMART | |||||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||
SwissProt | Q15019 | ||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q15019 | ||||||||||||||||||||||||
TrEMBL | C9JTV8 | ||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 4735 | ||||||||||||||||||||||||
UniGene | Hs.721234 | ||||||||||||||||||||||||
RefSeq | NP_001269902 | ||||||||||||||||||||||||
HUGO | HGNC:7729 | ||||||||||||||||||||||||
OMIM | 601506 | ||||||||||||||||||||||||
CCDS | CCDS63195 | ||||||||||||||||||||||||
HPRD | 03297 | ||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | AC005104 AC104841 AF038404 AK294563 BC014455 BC033559 D28540 D63878 | ||||||||||||||||||||||||
GenPept | AAB92377 AAH14455 AAH33559 AAY14718 BAA05893 BAA09928 BAG57759 | ||||||||||||||||||||||||