InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL18R1

Summary

InnateDB Protein

IDBP-295111.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL18R1

Protein Name

interleukin 18 receptor 1

Synonyms

CD218a; CDw218a; IL-1Rrp; IL18RA; IL1RRP;

Species

Homo sapiens

Ensembl Protein

ENSP00000387211

InnateDB Gene

IDBG-64199 (IL18R1)

Protein Structure

UniProt Annotation

Function

Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression in Hodgkin disease cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	6 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004908	interleukin-1 receptor activity
GO:0005515	protein binding
GO:0042008	interleukin-18 receptor activity

Biological Process

GO:0006955	immune response
GO:0007165	signal transduction
GO:0030101	natural killer cell activation
GO:0032729	positive regulation of interferon-gamma production
GO:0035655	interleukin-18-mediated signaling pathway
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0045063	T-helper 1 cell differentiation

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR003599 Immunoglobulin subtype
IPR004074 Interleukin-1 receptor type I/II
IPR007110 Immunoglobulin-like domain

PFAM

PF01582
PF13676

PRINTS

PR01536

PIRSF

SMART

SM00255
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt