InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CPE

Summary

InnateDB Protein

IDBP-295117.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CPE

Protein Name

carboxypeptidase E

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000386104

InnateDB Gene

IDBG-43626 (CPE)

Protein Structure

UniProt Annotation

Function

Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.

Subcellular Localization

Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. {ECO:0000250}.Isoform 2: Nucleus.

Disease Associations

Tissue Specificity

Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas. {ECO:0000269PubMed:21285511}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004180	carboxypeptidase activity
GO:0004181	metallocarboxypeptidase activity
GO:0008270	zinc ion binding
GO:0042043	neurexin family protein binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0003214	cardiac left ventricle morphogenesis
GO:0006464	cellular protein modification process
GO:0006508	proteolysis
GO:0007218	neuropeptide signaling pathway
GO:0008152	metabolic process
GO:0030070	insulin processing
GO:0044267	cellular protein metabolic process
GO:0072657	protein localization to membrane

Cellular Component

GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0030658	transport vesicle membrane
GO:0030667	secretory granule membrane
GO:0070062	extracellular vesicular exosome