Version 5.4
Homo sapiens Protein: ZNF653
Summary
InnateDB Protein IDBP-29525.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZNF653
Protein Name zinc finger protein 653
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000293771
InnateDB Gene IDBG-29523 (ZNF653)
Protein Structure
UniProt Annotation
Function Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity. {ECO:0000269PubMed:12920234}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in testis, cerebellum, temporal lobe, hippocampus and the adrenal gland. Moderately expressed in spleen, uterus, thymus, pancreas, kidney, stomach and rectum.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96CK0
PhosphoSite PhosphoSite-Q96CK0
TrEMBL A0A024R7E6
UniProt Splice Variant
Entrez Gene 115950
UniGene Hs.465928
RefSeq NP_620138
HUGO HGNC:25196
OMIM 611371
CCDS CCDS12261
HPRD 15889
IMGT
EMBL AY072704 BC014187 BC016816 CH471106
GenPept AAH14187 AAH16816 AAL66763 EAW84222 EAW84226

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca