InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFIA

Summary

InnateDB Protein

IDBP-295304.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFIA

Protein Name

nuclear factor I/A

Synonyms

CTF; NF-I/A; NF1-A; NFI-A; NFI-L;

Species

Homo sapiens

Ensembl Protein

ENSP00000384523

InnateDB Gene

IDBG-99286 (NFIA)

Protein Structure

UniProt Annotation

Function

Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	33 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding

Biological Process

GO:0006260	DNA replication
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0019079	viral genome replication
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000647 CTF transcription factor/nuclear factor 1
IPR003619 MAD homology 1, Dwarfin-type
IPR019548 CTF transcription factor/nuclear factor 1, N-terminal
IPR020604 CTF transcription factor/nuclear factor 1, DNA-binding domain

PFAM

PF00859
PF03165
PF10524

PRINTS

PIRSF

SMART

SM00523

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q12857