InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD8A

Summary

InnateDB Protein

IDBP-295331.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD8A

Protein Name

CD8a molecule

Synonyms

CD8; Leu2; MAL; p32;

Species

Homo sapiens

Ensembl Protein

ENSP00000386559

InnateDB Gene

IDBG-59987 (CD8A)

Protein Structure

UniProt Annotation

Function

Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.

Disease Associations

CD8 deficiency, familial (CD8 deficiency) [MIM:608957]: An immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. {ECO:0000269PubMed:11435463}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015026	coreceptor activity
GO:0019901	protein kinase binding
GO:0042288	MHC class I protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0002456	T cell mediated immunity
GO:0006955	immune response
GO:0007166	cell surface receptor signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0019882	antigen processing and presentation
GO:0042110	T cell activation
GO:0045065	cytotoxic T cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0050776	regulation of immune response
GO:0050850	positive regulation of calcium-mediated signaling
GO:0051607	defense response to virus

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0042101	T cell receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF07686
PF00047

PRINTS

PIRSF

SMART

SM00406
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P01732