Homo sapiens Protein: CAPG
Summary
InnateDB Protein IDBP-295389.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPG
Protein Name capping protein (actin filament), gelsolin-like
Synonyms AFCP; HEL-S-66; MCP;
Species Homo sapiens
Ensembl Protein ENSP00000386965
InnateDB Gene IDBG-59043 (CAPG)
Protein Structure
UniProt Annotation
Function Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:17081065}. Nucleus {ECO:0000269PubMed:17081065}. Melanosome {ECO:0000269PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Disease Associations
Tissue Specificity Macrophages and macrophage-like cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0006461 protein complex assembly
GO:0051016 barbed-end actin filament capping
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0008290 F-actin capping protein complex
GO:0031965 nuclear membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR007122 Villin/Gelsolin
IPR007123 Gelsolin-like domain
PFAM PF00626
PRINTS PR00597
PIRSF
SMART SM00262
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P40121
PhosphoSite PhosphoSite-P40121
TrEMBL V9HW69
UniProt Splice Variant
Entrez Gene 822
UniGene Hs.687978
RefSeq NP_001243068
HUGO HGNC:1474
OMIM 153615
CCDS CCDS1974
HPRD 01088
IMGT
EMBL AC062037 AK225374 AK300507 BC000728 BC014549 CH471053 FJ224312 M94345 U12026
GenPept AAA59570 AAA92670 AAH00728 AAH14549 AAY24128 ACI46004 BAG62220 EAW99517 EAW99518 EAW99519 EAW99520