InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SVEP1

Summary

InnateDB Protein

IDBP-295396.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SVEP1

Protein Name

sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384917

InnateDB Gene

IDBG-80388 (SVEP1)

Protein Structure

UniProt Annotation

Function

May play a role in the cell attachment process. {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000305}. Cytoplasm {ECO:0000269PubMed:16206243}. Membrane {ECO:0000269PubMed:16206243}; Peripheral membrane protein {ECO:0000269PubMed:16206243}.

Disease Associations

Tissue Specificity

Present in mesenchymal primary cultured cell lysates (at protein level). Highly expressed in placenta. Also expressed in marrow stromal cell. Weakly or not expressed in other tissues. {ECO:0000269PubMed:11062057, ECO:0000269PubMed:16206243}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007155

cell adhesion

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000436 Sushi/SCR/CCP
IPR000742 Epidermal growth factor-like domain
IPR001759 Pentaxin
IPR001881 EGF-like calcium-binding domain
IPR002035 von Willebrand factor, type A
IPR003410 Hyalin
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
IPR013111 EGF-like domain, extracellular

PFAM