Homo sapiens Protein: CADM2 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-295399.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | CADM2 | ||||||||||||||
Protein Name | cell adhesion molecule 2 | ||||||||||||||
Synonyms | |||||||||||||||
Species | Homo sapiens | ||||||||||||||
Ensembl Protein | ENSP00000384193 | ||||||||||||||
InnateDB Gene | IDBG-45644 (CADM2) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. {ECO:0000269PubMed:17967169}. | ||||||||||||||
Subcellular Localization | Cell membrane {ECO:0000269PubMed:17967169}; Single-pass type I membrane protein {ECO:0000269PubMed:17967169}. Cell junction, synapse {ECO:0000269PubMed:17967169}. Cell projection, axon {ECO:0000269PubMed:17967169}. Note=Found in the axoplasm of myelinated axons. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | |||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | |||||||||||||||
InterPro |
IPR003585
Neurexin/syndecan/glycophorin C IPR003597 Immunoglobulin C1-set IPR003598 Immunoglobulin subtype 2 IPR003599 Immunoglobulin subtype IPR007110 Immunoglobulin-like domain IPR013098 Immunoglobulin I-set IPR013106 Immunoglobulin V-set domain IPR013151 Immunoglobulin IPR013162 CD80-like, immunoglobulin C2-set |
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PFAM |
PF07654
PF07679 PF07686 PF00047 PF08205 |
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PRINTS | |||||||||||||||
PIRSF | |||||||||||||||
SMART |
SM00294
SM00407 SM00408 SM00409 |
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TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q8N3J6 | ||||||||||||||
PhosphoSite | PhosphoSite-Q8N3J6 | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 253559 | ||||||||||||||
UniGene | Hs.735502 | ||||||||||||||
RefSeq | NP_694854 | ||||||||||||||
HUGO | HGNC:29849 | ||||||||||||||
OMIM | 609938 | ||||||||||||||
CCDS | CCDS33792 | ||||||||||||||
HPRD | 11046 | ||||||||||||||
IMGT | |||||||||||||||
EMBL | AB646740 AB646741 AB646742 AB646743 AF538973 AL833049 AL834270 BC105999 | ||||||||||||||
GenPept | AAI06000 AAN16368 BAK93303 BAK93304 BAK93305 BAK93306 CAD38945 CAH56314 | ||||||||||||||