InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRABD2A

Summary

InnateDB Protein

IDBP-295419.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRABD2A

Protein Name

chromosome 2 open reading frame 89

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000387075

InnateDB Gene

IDBG-58822 (TRABD2A)

Protein Structure

UniProt Annotation

Function

Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N- terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation. {ECO:0000269PubMed:22726442}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:22726442}; Single-pass type I membrane protein {ECO:0000269PubMed:22726442}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0017147	Wnt-protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0008152	metabolic process
GO:0016055	Wnt signaling pathway
GO:0018158	protein oxidation
GO:0030178	negative regulation of Wnt signaling pathway
GO:0060322	head development