InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCMF1

Summary

InnateDB Protein

IDBP-295426.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCMF1

Protein Name

potassium channel modulatory factor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000386738

InnateDB Gene

IDBG-58874 (KCMF1)

Protein Structure

UniProt Annotation

Function

Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. {ECO:0000269PubMed:15581609}.

Subcellular Localization

Disease Associations

Tissue Specificity

Spleen, small intestine, ovary, peripheral blood, lung, kidney and pancreas. Expressed at low levels in the thymus, prostate, testis, colon, heart, brain, placenta and liver. {ECO:0000269PubMed:15581609}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0008152

metabolic process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000433 Zinc finger, ZZ-type
IPR007087 Zinc finger, C2H2
IPR008598 Drought induced 19 protein-like, zinc-binding domain
IPR015880 Zinc finger, C2H2-like

PFAM

PF00569
PF00096
PF05605

PRINTS

PIRSF

SMART

SM00291
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9P0J7