InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DGKA

Summary

InnateDB Protein

IDBP-295440.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DGKA

Protein Name

diacylglycerol kinase, alpha 80kDa

Synonyms

DAGK; DAGK1; DGK-alpha;

Species

Homo sapiens

Ensembl Protein

ENSP00000385792

InnateDB Gene

IDBG-39397 (DGKA)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005509	calcium ion binding
GO:0005524	ATP binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007596	blood coagulation
GO:0016310	phosphorylation
GO:0030168	platelet activation
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002048 EF-hand domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

PFAM

PF00036
PF13202
PF13405
PF00130

PRINTS

PIRSF

SMART

SM00054
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P23743

PhosphoSite

PhosphoSite-P23743

TrEMBL

G3V4I3

UniProt Splice Variant

Entrez Gene

1606

UniGene

Hs.595019

RefSeq

HUGO

HGNC:2849

OMIM

125855

CCDS

HPRD

00517

IMGT

EMBL

AC025162 AF064767 AF064768 AF064769 AF064771 AY930112 BC023523 BC031870 X62535

GenPept

AAC34802 AAC34803 AAC34804 AAC34806 AAH23523 AAH31870 AAY20994 CAA44396