Version 5.4
Homo sapiens Protein: SYCE3
Summary
InnateDB Protein IDBP-295525.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYCE3
Protein Name synaptonemal complex central element protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000385480
InnateDB Gene IDBG-281630 (SYCE3)
Protein Structure
UniProt Annotation
Function Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Colocalizes with SYCE1 in the central elements. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007130 synaptonemal complex assembly
GO:0007131 reciprocal meiotic recombination
GO:0007283 spermatogenesis
GO:0043065 positive regulation of apoptotic process
Cellular Component
GO:0000801 central element
GO:0005634 nucleus
GO:0005694 chromosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A1L190
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 644186
UniGene Hs.535660
RefSeq NP_001116697
HUGO HGNC:35245
OMIM 615775
CCDS CCDS46733
HPRD
IMGT
EMBL BC127859 BC127860 CH471138 EU082028
GenPept AAI27860 AAI27861 ABU52998 EAW73567

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca