InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STAMBP

Summary

InnateDB Protein

IDBP-295546.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAMBP

Protein Name

STAM binding protein

Synonyms

AMSH; MICCAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000386548

InnateDB Gene

IDBG-56678 (STAMBP)

Protein Structure

UniProt Annotation

Function

Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. {ECO:0000250, ECO:0000269PubMed:10383417, ECO:0000269PubMed:11483516, ECO:0000269PubMed:15314065, ECO:0000269PubMed:17261583, ECO:0000269PubMed:23542699}.

Subcellular Localization

Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome.

Disease Associations

Microcephaly-capillary malformation syndrome (MICCAP) [MIM:614261]: A congenital disorder characterized by severe progressive microcephaly, early-onset refractory epilepsy, profound developmental delay, and multiple small capillary malformations spread diffusely on the body. Additional more variable features include dysmorphic facial features, distal limb abnormalities, and mild heart defects. {ECO:0000269PubMed:23542699}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitously expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	76 [view]
Protein-Protein	74 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0046872	metal ion binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0006508	proteolysis
GO:0007259	JAK-STAT cascade
GO:0008284	positive regulation of cell proliferation
GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling
GO:0016579	protein deubiquitination
GO:0046580	negative regulation of Ras protein signal transduction

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005886	plasma membrane
GO:0032154	cleavage furrow
GO:0070062	extracellular vesicular exosome