InnateDB Protein
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IDBP-295575.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IFI30
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Protein Name
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interferon, gamma-inducible protein 30
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Synonyms
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GILT; IFI-30; IP30;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000384886
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InnateDB Gene
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IDBG-281623 (IFI30)
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Protein Structure
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Function |
Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II- restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted. Lysosome.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
0
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0016667
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oxidoreductase activity, acting on a sulfur group of donors
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Biological Process |
GO:0019221
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cytokine-mediated signaling pathway
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GO:0019886
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antigen processing and presentation of exogenous peptide antigen via MHC class II
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GO:0042590
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antigen processing and presentation of exogenous peptide antigen via MHC class I
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GO:0048147
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negative regulation of fibroblast proliferation
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GO:0050821
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protein stabilization
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GO:0055114
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oxidation-reduction process
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GO:0060333
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interferon-gamma-mediated signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR004911
Gamma interferon inducible lysosomal thiol reductase GILT
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PFAM |
PF03227
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P13284
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PhosphoSite |
PhosphoSite-P13284
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TrEMBL |
M0QZG3
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UniProt Splice Variant |
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Entrez Gene |
10437
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UniGene |
Hs.708970
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RefSeq |
NP_006323
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HUGO |
HGNC:5398
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OMIM |
604664
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CCDS |
CCDS46015
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HPRD |
05234
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IMGT |
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EMBL |
AB049659
AC007192
AC068499
AC093080
AF097362
BC021136
BC031020
CH471106
J03909
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GenPept |
AAA36105
AAF04618
AAH21136
AAH31020
BAC98466
EAW84662
EAW84665
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