Version 5.4
Homo sapiens Protein: GRAMD4
Summary
InnateDB Protein IDBP-295616.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRAMD4
Protein Name GRAM domain containing 4
Synonyms dA59H18.1; DIP; dJ439F8.1;
Species Homo sapiens
Ensembl Protein ENSP00000385689
InnateDB Gene IDBG-12191 (GRAMD4)
Protein Structure
UniProt Annotation
Function Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. {ECO:0000269PubMed:15565177}.
Subcellular Localization Mitochondrion membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}. Note=Colocalizes with COX4I1. {ECO:0000269PubMed:15565177}.
Disease Associations
Tissue Specificity Expressed in lung and in primary lung squamous cell carcinoma (LSCC). {ECO:0000269PubMed:18302964}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006915 apoptotic process
Cellular Component
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Protein Structure and Domains
PDB ID
InterPro IPR004182 GRAM domain
PFAM PF02893
PRINTS
PIRSF
SMART SM00568
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6IC98
PhosphoSite PhosphoSite-Q6IC98
TrEMBL X6RIP6
UniProt Splice Variant
Entrez Gene 23151
UniGene Hs.475150
RefSeq XP_005261453
HUGO HGNC:29113
OMIM 613691
CCDS CCDS33672
HPRD 11107
IMGT
EMBL AB018310 AL021392 AL096766 BC080189 BC129837 CH471138 CR456470
GenPept AAH80189 AAI29838 BAA34487 CAG30356 CAI18820 CAI20966 CAP58794 CAP58795 CAQ07606 EAW73432

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca