InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP3A4

Summary

InnateDB Protein

IDBP-29573.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP3A4

Protein Name

cytochrome P450, family 3, subfamily A, polypeptide 4

Synonyms

CP33; CP34; CYP3A; CYP3A3; CYPIIIA3; CYPIIIA4; HLP; NF-25; P450C3; P450PCN1;

Species

Homo sapiens

Ensembl Protein

ENSP00000337915

InnateDB Gene

IDBG-29569 (CYP3A4)

Protein Structure

UniProt Annotation

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2- exo-monooxygenase. The enzyme also hydroxylates etoposide. {ECO:0000269PubMed:11159812}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level). {ECO:0000269PubMed:18545703, ECO:0000269PubMed:19094056, ECO:0000269PubMed:19359404, ECO:0000269PubMed:2732228, ECO:0000269PubMed:7894497, ECO:0000269PubMed:8035341}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	10 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005496	steroid binding
GO:0005506	iron ion binding
GO:0008395	steroid hydroxylase activity
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019825	oxygen binding
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0030343	vitamin D3 25-hydroxylase activity
GO:0033780	taurochenodeoxycholate 6alpha-hydroxylase activity
GO:0034875	caffeine oxidase activity
GO:0047638	albendazole monooxygenase activity
GO:0050591	quinine 3-monooxygenase activity
GO:0050649	testosterone 6-beta-hydroxylase activity
GO:0070576	vitamin D 24-hydroxylase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006706	steroid catabolic process
GO:0006805	xenobiotic metabolic process
GO:0008202	steroid metabolic process
GO:0008209	androgen metabolic process
GO:0009822	alkaloid catabolic process
GO:0016098	monoterpenoid metabolic process
GO:0017144	drug metabolic process
GO:0036378	calcitriol biosynthetic process from calciol
GO:0042359	vitamin D metabolic process
GO:0042737	drug catabolic process
GO:0042738	exogenous drug catabolic process
GO:0044281	small molecule metabolic process
GO:0046483	heterocycle metabolic process
GO:0055114	oxidation-reduction process
GO:0070989	oxidative demethylation

Cellular Component

GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002401 Cytochrome P450, E-class, group I
IPR002402 Cytochrome P450, E-class, group II
IPR002403 Cytochrome P450, E-class, group IV
IPR008072 Cytochrome P450, E-class, CYP3A

PFAM

PF00067

PRINTS

PR00385
PR00359
PR00463
PR00464
PR00465
PR01689

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08684