Homo sapiens Protein: CNN1
Summary
InnateDB Protein IDBP-29602.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNN1
Protein Name calponin 1, basic, smooth muscle
Synonyms HEL-S-14; Sm-Calp; SMCC;
Species Homo sapiens
Ensembl Protein ENSP00000252456
InnateDB Gene IDBG-29600 (CNN1)
Protein Structure
UniProt Annotation
Function Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity Smooth muscle, and tissues containing significant amounts of smooth muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
GO:0006940 regulation of smooth muscle contraction
GO:0031032 actomyosin structure organization
Cellular Component
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR000557 Calponin repeat
IPR001715 Calponin homology domain
IPR001997 Calponin
IPR003096 Smooth muscle protein/calponin
PFAM PF00402
PF00307
PRINTS PR00889
PR00888
PIRSF
SMART SM00033
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P51911
PhosphoSite PhosphoSite-P51911
TrEMBL V9HWA5
UniProt Splice Variant
Entrez Gene 1264
UniGene Hs.708990
RefSeq NP_001290
HUGO HGNC:2155
OMIM 600806
CCDS CCDS12263
HPRD 02884
IMGT
EMBL AC008481 AK301888 AK313255 AK316406 BC022015 BC036307 CH471106 D17408 D85611 D86058 EU794601 S80560 U37019
GenPept AAB35751 AAC51780 AAH22015 AAH36307 ACJ13655 BAA04231 BAA12983 BAA19538 BAG36065 BAH13577 BAH14777 EAW84229