InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TSPYL5

Summary

InnateDB Protein

IDBP-29608.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TSPYL5

Protein Name

TSPY-like 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000322802

InnateDB Gene

IDBG-29606 (TSPYL5)

Protein Structure

UniProt Annotation

Function

Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7. {ECO:0000269PubMed:20079711, ECO:0000269PubMed:21170034}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006334	nucleosome assembly
GO:0008284	positive regulation of cell proliferation
GO:0031398	positive regulation of protein ubiquitination
GO:0040008	regulation of growth
GO:0051897	positive regulation of protein kinase B signaling
GO:0071480	cellular response to gamma radiation