InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: F2R

Summary

InnateDB Protein

IDBP-29673.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F2R

Protein Name

coagulation factor II (thrombin) receptor

Synonyms

CF2R; HTR; PAR-1; PAR1; TR;

Species

Homo sapiens

Ensembl Protein

ENSP00000321326

InnateDB Gene

IDBG-29671 (F2R)

Protein Structure

UniProt Annotation

Function

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. {ECO:0000269PubMed:10079109}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Platelets and vascular endothelial cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004930	G-protein coupled receptor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0015057	thrombin receptor activity
GO:0031681	G-protein beta-subunit binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0002248	connective tissue replacement involved in inflammatory response wound healing
GO:0003105	negative regulation of glomerular filtration
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007260	tyrosine phosphorylation of STAT protein
GO:0007262	STAT protein import into nucleus
GO:0007529	establishment of synaptic specificity at neuromuscular junction
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009611	response to wounding
GO:0009653	anatomical structure morphogenesis
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016265	death
GO:0030168	platelet activation
GO:0030193	regulation of blood coagulation
GO:0030194	positive regulation of blood coagulation
GO:0030335	positive regulation of cell migration
GO:0032496	response to lipopolysaccharide
GO:0032651	regulation of interleukin-1 beta production
GO:0032967	positive regulation of collagen biosynthetic process
GO:0035025	positive regulation of Rho protein signal transduction
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043410	positive regulation of MAPK cascade
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045907	positive regulation of vasoconstriction
GO:0045987	positive regulation of smooth muscle contraction
GO:0046427	positive regulation of JAK-STAT cascade
GO:0048873	homeostasis of number of cells within a tissue
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051928	positive regulation of calcium ion transport
GO:0051930	regulation of sensory perception of pain
GO:0060155	platelet dense granule organization
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070493	thrombin receptor signaling pathway
GO:1900134	negative regulation of renin secretion into blood stream
GO:2000484	positive regulation of interleukin-8 secretion
GO:2000778	positive regulation of interleukin-6 secretion

Cellular Component

GO:0005576	extracellular region
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0016021	integral component of membrane
GO:0031094	platelet dense tubular network
GO:0031594	neuromuscular junction
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000935 Thrombin receptor
IPR003912 Protease-activated receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00908
PR01428

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P25116