InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STX8

Summary

InnateDB Protein

IDBP-29712.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STX8

Protein Name

syntaxin 8

Synonyms

CARB;

Species

Homo sapiens

Ensembl Protein

ENSP00000305255

InnateDB Gene

IDBG-29710 (STX8)

Protein Structure

UniProt Annotation

Function

Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Preferentially associated with the early endosome. To lesser extends, also present in late endosome, the plasma membrane and coated pits (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005484	SNAP receptor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0006906	vesicle fusion
GO:0008333	endosome to lysosome transport
GO:0016192	vesicle-mediated transport

Cellular Component

GO:0005765	lysosomal membrane
GO:0005783	endoplasmic reticulum
GO:0005887	integral component of plasma membrane
GO:0031201	SNARE complex
GO:0031902	late endosome membrane