InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGGF1

Summary

InnateDB Protein

IDBP-29865.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGGF1

Protein Name

angiogenic factor with G patch and FHA domains 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000316109

InnateDB Gene

IDBG-29861 (AGGF1)

Protein Structure

UniProt Annotation

Function

Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. {ECO:0000269PubMed:14961121}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14961121}. Secreted {ECO:0000269PubMed:14961121}. Note=Cytoplasmic in microvascular endothelial cells. Upon angiogenesis, when endothelial cell tube formation is initiated, it is secreted.

Disease Associations

Klippel-Trenaunay syndrome (KTS) [MIM:149000]: Congenital disease characterized by malformations of capillary (98% of KTS patients), venous (72%) and lymphatic (11%) vessels, and bony and soft tissue hypertrophy that leads to large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues. {ECO:0000269PubMed:14961121}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed. Expressed in endothelial cells, vascular smooth muscle cells and osteoblasts. Expressed in umbilical vein endothelial cells and microvascular endothelial cells. {ECO:0000269PubMed:14961121}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001570	vasculogenesis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006396	RNA processing
GO:0007155	cell adhesion
GO:0045766	positive regulation of angiogenesis