InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FYCO1

Summary

InnateDB Protein

IDBP-29900.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FYCO1

Protein Name

FYVE and coiled-coil domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000296137

InnateDB Gene

IDBG-29898 (FYCO1)

Protein Structure

UniProt Annotation

Function

May mediate microtubule plus end-directed vesicle transport. {ECO:0000269PubMed:20100911}.

Subcellular Localization

Cytoplasmic vesicle, autophagosome. Endosome. Lysosome. Note=Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes.

Disease Associations

Cataract 18 (CTRCT18) [MIM:610019]: An opacification of the crystalline lens of the eye becoming evident at birth or in infancy. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. {ECO:0000269PubMed:21636066}. Note=The disease is caused by mutations affecting the gene represented in this entry. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (PubMed:21636066). {ECO:0000269PubMed:21636066}.

Tissue Specificity

Expressed in heart and skeletal muscle. {ECO:0000269PubMed:11896456}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.

Experimentally validated
Total	31 [view]
Protein-Protein	30 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006810	transport
GO:0072383	plus-end-directed vesicle transport along microtubule

Cellular Component

GO:0005764	lysosome
GO:0005770	late endosome
GO:0005776	autophagic vacuole
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR000306 FYVE zinc finger
IPR004012 RUN
IPR009038 GOLD
IPR009053 Prefoldin
IPR010978 tRNA-binding arm
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related

PFAM

PF01363
PF02759
PF01105
PF13897

PRINTS

PIRSF

SMART

SM00064
SM00593

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BQS8