Version 5.4
Homo sapiens Protein: H1FNT
Summary
InnateDB Protein IDBP-29950.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H1FNT
Protein Name H1 histone family, member N, testis-specific
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000334805
InnateDB Gene IDBG-29948 (H1FNT)
Protein Structure
UniProt Annotation
Function Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone- protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=In round and elongating spermatids, specifically localizes to a chromatin domain at the apical pole. {ECO:0000250}.
Disease Associations
Tissue Specificity Testis-specific. {ECO:0000269PubMed:16533358}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005524 ATP binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007290 spermatid nucleus elongation
GO:0030261 chromosome condensation
GO:0035092 sperm chromatin condensation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q75WM6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 341567
UniGene Hs.155833
RefSeq NP_861453
HUGO HGNC:24893
OMIM
CCDS CCDS8762
HPRD 17084
IMGT
EMBL AB121028 AC024257 AY302593 AY496854 BC118635 BC119787
GenPept AAI18636 AAI19788 AAP60022 AAS49492 BAD13382

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca