InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZBED3

Summary

InnateDB Protein

IDBP-29992.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZBED3

Protein Name

zinc finger, BED-type containing 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000255198

InnateDB Gene

IDBG-29988 (ZBED3)

Protein Structure

UniProt Annotation

Function

Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Colocalizes with AXIN1 in the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	0
Protein-DNA	4 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0016055	Wnt signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050821	protein stabilization
GO:0090263	positive regulation of canonical Wnt signaling pathway