InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCR1

Summary

InnateDB Protein

IDBP-30087.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCR1

Protein Name

chemokine (C-C motif) receptor 1

Synonyms

CD191; CKR-1; CKR1; CMKBR1; HM145; MIP1aR; SCYAR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000296140

InnateDB Gene

IDBG-30085 (CCR1)

Protein Structure

UniProt Annotation

Function

Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:18587271}; Multi-pass membrane protein {ECO:0000269PubMed:18587271}.

Disease Associations

Tissue Specificity

Widely expressed in different hematopoietic cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	19 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity
GO:0019957	C-C chemokine binding
GO:0035717	chemokine (C-C motif) ligand 7 binding
GO:0071791	chemokine (C-C motif) ligand 5 binding

Biological Process

GO:0002407	dendritic cell chemotaxis
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006887	exocytosis
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007155	cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007267	cell-cell signaling
GO:0008152	metabolic process
GO:0009611	response to wounding
GO:0010629	negative regulation of gene expression
GO:0019221	cytokine-mediated signaling pathway
GO:0030502	negative regulation of bone mineralization
GO:0045672	positive regulation of osteoclast differentiation
GO:0051928	positive regulation of calcium ion transport
GO:0070098	chemokine-mediated signaling pathway
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090026	positive regulation of monocyte chemotaxis

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR000611 Neuropeptide Y receptor family
IPR002236 CC chemokine receptor 1
IPR002240 CC chemokine receptor 5
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00241
PR00237
PR00657
PR01012
PR01106
PR01110

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32246