InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SIM2

Summary

InnateDB Protein

IDBP-3009.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIM2

Protein Name

single-minded homolog 2 (Drosophila)

Synonyms

bHLHe15; HMC13F06; HMC29C01; SIM;

Species

Homo sapiens

Ensembl Protein

ENSP00000290399

InnateDB Gene

IDBG-3007 (SIM2)

Protein Structure

UniProt Annotation

Function

Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00632, ECO:0000255PROSITE-ProRule:PRU00981, ECO:0000269PubMed:14697214}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0009880	embryonic pattern specification
GO:0030154	cell differentiation
GO:0030324	lung development
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000014 PAS domain
IPR001610 PAC motif
IPR010578 Single-minded, C-terminal
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013655 PAS fold-3
IPR013767 PAS fold

PFAM

PF13188
PF13426
PF06621
PF00010
PF08447
PF00989

PRINTS

PIRSF

SMART

SM00091
SM00086
SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14190