InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYH13

Summary

InnateDB Protein

IDBP-30111.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYH13

Protein Name

myosin, heavy chain 13, skeletal muscle

Synonyms

MyHC-eo; MyHC-IIL;

Species

Homo sapiens

Ensembl Protein

ENSP00000252172

InnateDB Gene

IDBG-30109 (MYH13)

Protein Structure

UniProt Annotation

Function

Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles. {ECO:0000269PubMed:23908353}.

Subcellular Localization

Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.

Disease Associations

Tissue Specificity

Specifically expressed in extraocular and laryngeal muscles. {ECO:0000269PubMed:12110653}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding

Biological Process

GO:0006936	muscle contraction
GO:0008152	metabolic process

Cellular Component

GO:0005859	muscle myosin complex
GO:0016459	myosin complex
GO:0030016	myofibril
GO:0032982	myosin filament
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR002928 Myosin tail
IPR004009 Myosin, N-terminal, SH3-like
IPR009053 Prefoldin
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF01576
PF02736

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt