InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NTSR2

Summary

InnateDB Protein

IDBP-30148.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NTSR2

Protein Name

neurotensin receptor 2

Synonyms

NTR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000303686

InnateDB Gene

IDBG-30146 (NTSR2)

Protein Structure

UniProt Annotation

Function

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in prostate (at protein level). {ECO:0000269PubMed:20048080}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0016492	G-protein coupled neurotensin receptor activity

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007600	sensory perception
GO:0042391	regulation of membrane potential

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR003984 Neurotensin receptor
IPR003986 Neurotensin type 2 receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR01479
PR01481

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95665