InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYB5R2

Summary

InnateDB Protein

IDBP-30160.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYB5R2

Protein Name

cytochrome b5 reductase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000299498

InnateDB Gene

IDBG-30156 (CYB5R2)

Protein Structure

UniProt Annotation

Function

NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4- disulfophenyl]-2H tetrazolium monosodium salt (WST-1). {ECO:0000250, ECO:0000269PubMed:15858218}.

Subcellular Localization

Disease Associations

Tissue Specificity

Restricted expression. {ECO:0000269PubMed:10611283}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0016491	oxidoreductase activity

Biological Process

GO:0016126	sterol biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
IPR001834 NADH:cytochrome b5 reductase (CBR)
IPR008333 Oxidoreductase, FAD-binding domain
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF00175
PF00970

PRINTS

PR00371
PR00406

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6BCY4