Version 5.4
Homo sapiens Protein: GJC3
Summary
InnateDB Protein IDBP-30175.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GJC3
Protein Name gap junction protein, gamma 3, 30.2kDa
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000325775
InnateDB Gene IDBG-30173 (GJC3)
Protein Structure
UniProt Annotation
Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
Disease Associations
Tissue Specificity CNS specific. Expression is restricted to brain, spinal cord, and sciatic nerve. According to PubMed:12881038, expression is abundant in skeletal muscle, liver, and heart, and to a minor degree in pancreas and kidney. {ECO:0000269PubMed:12151525, ECO:0000269PubMed:12881038}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0042803 protein homodimerization activity
Biological Process
GO:0007154 cell communication
GO:0007605 sensory perception of sound
GO:0042552 myelination
Cellular Component
GO:0005922 connexon complex
GO:0016021 integral component of membrane
GO:0043209 myelin sheath
Protein Structure and Domains
PDB ID
InterPro IPR000500 Connexin
IPR013092 Connexin, N-terminal
IPR019570 Gap junction protein, cysteine-rich domain
PFAM PF00029
PF10582
PRINTS PR00206
PIRSF
SMART SM00037
SM01089
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NFK1
PhosphoSite PhosphoSite-Q8NFK1
TrEMBL
UniProt Splice Variant
Entrez Gene 349149
UniGene Hs.647524
RefSeq NP_853516
HUGO HGNC:17495
OMIM 611925
CCDS CCDS34697
HPRD 13580
IMGT
EMBL AF503615 AY297109 BC043381 CH236956 CH471091
GenPept AAH43381 AAM21145 AAP51161 EAL23863 EAW76624

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca