InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF136

Summary

InnateDB Protein

IDBP-30181.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF136

Protein Name

zinc finger protein 136

Synonyms

pHZ-20;

Species

Homo sapiens

Ensembl Protein

ENSP00000344162

InnateDB Gene

IDBG-30179 (ZNF136)

Protein Structure

UniProt Annotation

Function

May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter