InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: N4BP1

Summary

InnateDB Protein

IDBP-30203.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

N4BP1

Protein Name

NEDD4 binding protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000262384

InnateDB Gene

IDBG-30201 (N4BP1)

Protein Structure

UniProt Annotation

Function

Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Primarily localizes to the nucleolus. Also localizes to the PML nuclear bodies, when desumoylated (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in heart, lung, brain, liver, skeletal muscle, pancreas, kidney, spleen, testis and ovary. {ECO:0000269PubMed:9734811}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0031397	negative regulation of protein ubiquitination
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034644	cellular response to UV