InnateDB Protein
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IDBP-30464.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TUB
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Protein Name
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tubby homolog (mouse)
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Synonyms
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rd5;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000305426
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InnateDB Gene
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IDBG-30462 (TUB)
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Protein Structure
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Function |
Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. {ECO:0000250, ECO:0000269PubMed:19837063}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000007
Tubby, C-terminal
IPR005398
Tubby, N-terminal
IPR025659
Tubby C-terminal-like domain
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PFAM |
PF01167
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PRINTS |
PR01573
PR01574
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P50607
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PhosphoSite |
PhosphoSite-P50607
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TrEMBL |
Q9H4D2
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UniProt Splice Variant |
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Entrez Gene |
7275
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UniGene |
Hs.620904
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RefSeq |
NP_003311
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HUGO |
HGNC:12406
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OMIM |
601197
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CCDS |
CCDS7786
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HPRD |
03121
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IMGT |
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EMBL |
AJ277662
BC075031
BC075032
CH471064
U54644
U82467
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GenPept |
AAB53494
AAB53699
AAH75031
AAH75032
CAC14586
EAW68634
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