Version 5.4
Homo sapiens Protein: DSCR6
Summary
InnateDB Protein IDBP-3048.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DSCR6
Protein Name Down syndrome critical region gene 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000331734
InnateDB Gene IDBG-3046 (DSCR6)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed at a low level in fetal kidney and fetal brain. {ECO:0000269PubMed:10814524}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007507 heart development
GO:0008150 biological_process
GO:0060037 pharyngeal system development
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P57055
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 53820
UniGene Hs.254560
RefSeq NP_061835
HUGO HGNC:3047
OMIM 609892
CCDS CCDS13648
HPRD 10923
IMGT
EMBL AB037158 AB037159 AB037160 AB037161
GenPept BAA96867 BAA96868 BAA96869 BAA96870

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca