InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGS22

Summary

InnateDB Protein

IDBP-30493.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS22

Protein Name

regulator of G-protein signaling 22

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000354109

InnateDB Gene

IDBG-30491 (RGS22)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18703424}. Nucleus {ECO:0000269PubMed:18703424}. Note=Expressed in the cytoplasm of spermatogonia and spermatocytes. In spermatids, also expressed in the nucleus.

Disease Associations

Tissue Specificity

Testis-specific. Expressed in Leydig cells and spermatogenic cells from the spermatogonia to spermatid stages (at protein level). {ECO:0000269PubMed:18703424}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity

Biological Process

GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity