InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LMO1

Summary

InnateDB Protein

IDBP-30627.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LMO1

Protein Name

LIM domain only 1 (rhombotin 1)

Synonyms

RBTN1; RHOM1; TTG1;

Species

Homo sapiens

Ensembl Protein

ENSP00000338207

InnateDB Gene

IDBG-30625 (LMO1)

Protein Structure

UniProt Annotation

Function

May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. {ECO:0000269PubMed:1703797}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Note=A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.

Tissue Specificity

Expressed mainly in the central nervous. Low level of expression in other tissues including thymus. {ECO:0000269PubMed:2052354}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	10 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001781 Zinc finger, LIM-type

PFAM

PF00412

PRINTS

PIRSF

SMART