InnateDB Protein
|
IDBP-30639.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
ALS2CL
|
Protein Name
|
ALS2 C-terminal like
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000373248
|
InnateDB Gene
|
IDBG-30633 (ALS2CL)
|
Protein Structure
|
|
Function |
Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics. {ECO:0000269PubMed:15388334, ECO:0000269PubMed:16473597, ECO:0000269PubMed:17239822}.
|
Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:15388334, ECO:0000269PubMed:17239822}. Note=Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells.
|
Disease Associations |
|
Tissue Specificity |
Expressed in heart and kidney. {ECO:0000269PubMed:15388334}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR003123
Vacuolar sorting protein 9
|
PFAM |
PF02204
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q60I27
|
PhosphoSite |
PhosphoSite-Q60I27
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
259173
|
UniGene |
Hs.517937
|
RefSeq |
NP_877576
|
HUGO |
HGNC:20605
|
OMIM |
612402
|
CCDS |
CCDS43080
|
HPRD |
10643
|
IMGT |
|
EMBL |
AB107015
AC104304
AC134504
AK092455
AK093844
AK126505
AK131270
AK131273
BC042906
BC061883
BC075825
BC109233
CH471055
CR627258
|
GenPept |
AAH42906
AAH61883
AAH75825
AAI09234
BAC03895
BAC04237
BAC86572
BAD18448
BAD18450
BAD51817
CAH10367
EAW64777
|
|
|